A scalable assembly-free variable selection algorithm for biomarker discovery from metagenomes


Metagenomics holds great promises for deepening our knowledge of key bacterial driven processes, but metagenome assembly remains problematic, typically resulting in representation biases and discarding significant amounts of non-redundant sequence information. In order to alleviate constraints assembly can impose on downstream analyses, and/or to increase the fraction of raw reads assembled via targeted assemblies relying on pre-assembly binning steps, we developed a set of binning modules and evaluated their combination in a new “assembly-free” binning protocol.

BMC Bioinformatics 17(1):311, August 2016
Flag Counter